Virgin soil epidemic is a term coined by Alfred Crosby, [1] defining it as epidemics "in which the populations at risk have had no previous contact with the diseases that strike them and are therefore immunologically almost defenseless".

This means that, except for people with genetic immunity, all people in the affected society get the disease, and most (70-90%) die of it. Virgin soil epidemics … Each entry combines biological and social information to form a picture of the significance of epidemics that have shaped world history.The essays cover the areas of major pandemics, virgin soil epidemics, disruptive shocks, and epidemics of symbolic interest. A 'virgin soil' epidemic is one that hits a population which has never been exposed to the disease before.

Virgin-soil epidemics are those in which the populations at risk have had no previous contact with the diseases that strike them and are therefore immunologically almost defenseless. “Virgin-soil” epidemics sweep through populations with no prior exposure to a particular infectious disease and consequently no immunity to it.

Virgin Soil Epidemics as a Factor in the Aboriginal Depopulation in America Alfred W. Crosby URING the last few decades historians have demonstrated in- creasing concern with the influence of disease in history, par- ticularly the history of the New World.

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